Mouse LRP5 (Low Density Lipoprotein Receptor Related Protein 5) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Lrp5
Gene ID:	16973
Uniprot ID:	LRP5_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen.
Post Translational Modifications	Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.
Function	Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development. Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis.
Protein Name	Low-Density Lipoprotein Receptor-Related Protein 5 Lrp-5 Low-Density Lipoprotein Receptor-Related Protein 7 Lrp-7
Database Links	Reactome: R-MMU-3772470 Reactome: -MMU-4641262 Reactome: -MMU-4641263
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Endoplasmic Reticulum Chaperoned To The Plasma Membrane By Mesd
Alternative ELISA Names	Low-Density Lipoprotein Receptor-Related Protein 5 ELISA kit Lrp-5 ELISA kit Low-Density Lipoprotein Receptor-Related Protein 7 ELISA kit Lrp-7 ELISA kit Lrp5 ELISA kit Lr3 ELISA kit Lrp7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance