MOUSE Interleukin 1 alpha - (Animal Free) - (m-IL-1 alpha)

Cat# 200-87AF-5UG

Size : 5ug

Brand : Shenandoah

Contact local distributor :


Phone : +1 850 650 7790

Recombinant Mouse IL-1α / IL-1F1

Catalog ID
200-87
Size
5 µg 200-87-5UG
5 µg (Animal-Free) 200-87AF-5UG
20 µg 200-87-20UG
20 µg (Animal-Free) 200-87AF-20UG
100 µg 200-87-100UG
100 µg (Animal-Free) 200-87AF-100UG
500 µg 200-87-500UG
500 µg (Animal-Free) 200-87AF-500UG
1 mg 200-87-1MG
1 mg (Animal-Free) 200-87AF-1MG
Details

Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names None
Accession Number P01582
Source Genetically modified E.coli
Predicted Molecular Mass Monomer, 18.1 kDa (157 aa)
AA Sequence MSAPYTYQSD LRYKLMKLVR QKFVMNDSLN QTIYQDVDKH YLSTTWLNDL QQEVKFDMYA YSSGGDDSKY PVTLKISDSQ LFVSAQGEDQ PVLLKELPET PKLITGSETD LIFFWKSINS KNYFTSAAYP ELFIATKEQS RVHLARGLPS MTDFQIS
Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 0.1 EU/µg
Biological Activity (ED50) D10.G4.1 proliferation ≤ 0.01 ng/mL

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

IL-1alpha IL-1 alpha

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to-80°C as supplied.

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