General Info
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.051ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This DKK4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
Information
| Gene Symbol: | Dkk4 |
| Gene ID: | 234130 |
| Uniprot ID: | DKK4_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma or other biological fluids. |
Description
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 4Dickkopf-4Dkk-4 |
| Database Links | Reactome: R-MMU-3772470 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Dickkopf-Related Protein 4 ELISA kitDickkopf-4 ELISA kitDkk-4 ELISA kitDkk4 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance