Mouse CDK8 (Cyclin Dependent Kinase 8) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Cdk8
Gene ID:	264064
Uniprot ID:	CDK8_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Protein Name	Cyclin-Dependent Kinase 8 Cell Division Protein Kinase 8 Mediator Complex Subunit Cdk8 Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8
Database Links	Reactome: R-MMU-2173796
Cellular Localisation	Nucleus
Alternative ELISA Names	Cyclin-Dependent Kinase 8 ELISA kit Cell Division Protein Kinase 8 ELISA kit Mediator Complex Subunit Cdk8 ELISA kit Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 ELISA kit Cdk8 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance