Mouse CDH2 (Cadherin, Neuronal) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Cdh2
Gene ID:	12558
Uniprot ID:	CADH2_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in cardiac muscle (at protein level).
Post Translational Modifications	Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence. May be phosphorylated by OBSCN. O-glycosylated on Ser and Thr residues.
Function	Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Protein Name	Cadherin-2 Neural Cadherin N-Cadherin Cd Antigen Cd325
Database Links	Reactome: R-MMU-381426 Reactome: -MMU-418990 Reactome: -MMU-525793 Reactome: -MMU-8957275
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Sarcolemma Cell Junction Adherens Junction Desmosome Cell Surface Colocalizes With Tmem65 At The Intercalated Disk In Cardiomyocytes Colocalizes With Obscn At The Intercalated Disk And Sarcolemma In Cardiomyocytes
Alternative ELISA Names	Cadherin-2 ELISA kit Neural Cadherin ELISA kit N-Cadherin ELISA kit Cd Antigen Cd325 ELISA kit Cdh2 ELISA kit
output

Information sourced from Uniprot.org

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