Mouse CD14 (Cluster Of Differentiation 14) Sandwich ELISA Kit

Cat# NB-22-64266-96

Size : 96T

Brand : Neo Biotech

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  • Mouse CD14 (Cluster Of Differentiation 14) Sandwich ELISA Kit

General Info

Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.72ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This CD14 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs

Information

Gene Symbol: Cd14
Gene ID: 12475
Uniprot ID: CD14_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.

Description

Tissue Specificity Detected on peritoneal macrophages (at protein level). Cell surface expression detected in lung alveolar macrophages, dendritic macrophages and lung macrophages (at protein level).
Post Translational Modifications
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14
Database Links Reactome: R-MMU-140534
Reactome: -MMU-166016
Reactome: -MMU-166020
Reactome: -MMU-166166
Reactome: -MMU-2562578
Reactome: -MMU-5686938
Reactome: -MMU-6798695
Reactome: -MMU-936964
Reactome: -MMU-937041
Reactome: -MMU-937072
Reactome: -MMU-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Soluble
Secreted Forms Seem To Exist
They May Arise By Cleavage Of The Gpi Anchor
Alternative ELISA Names Monocyte Differentiation Antigen Cd14 ELISA kit
Myeloid Cell-Specific Leucine-Rich Glycoprotein ELISA kit
Cd Antigen Cd14 ELISA kit
Cd14 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance