Kmt5c Mouse Gene Knockout Kit (CRISPR)
CAT#: KN317008RB
Suv420h2 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | Kmt5c |
| Locus ID | 232811 |
| Components | KN317008G1, Kmt5c gRNA vector 1 in pCas-Guide CRISPR vector KN317008G2, Kmt5c gRNA vector 2 in pCas-Guide CRISPR vector KN317008RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_001115018, NM_146177, NM_001358044 |
| UniProt ID | Q6Q783 |
| Synonyms | BC024816; Suv4-20h2; Suv420h2 |
| Summary | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN317008 | Kmt5c - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN317008BN | Suv420h2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN317008LP | Suv420h2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN517008 | Suv420h2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA214382 | Kmt5c CRISPRa kit - CRISPR gene activation of mouse lysine methyltransferase 5C | 1 657,00 EUR |