JZL195 [1210004-12-8]
Cat# HY-15250-100mg
Size : 100mg
Brand : MedChemExpress
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively.
For research use only. We do not sell to patients.
JZL195 Chemical Structure
CAS No. : 1210004-12-8
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Description |
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively[1]. |
IC50 & Target |
IC50: 2 nM (FAAH), 4 nM (MAGL)[1] |
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In Vitro |
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
433.46 |
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Formula |
C24H23N3O5 |
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CAS No. |
1210004-12-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(OC1=CC=C([N+]([O-])=O)C=C1)N(CC2)CCN2CC3=CC(OC4=CC=CC=C4)=CC=C3 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 50 mg/mL (115.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.75% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.3070 mL | 11.5351 mL | 23.0702 mL | 57.6754 mL |
5 mM | 0.4614 mL | 2.3070 mL | 4.6140 mL | 11.5351 mL | |
10 mM | 0.2307 mL | 1.1535 mL | 2.3070 mL | 5.7675 mL | |
15 mM | 0.1538 mL | 0.7690 mL | 1.5380 mL | 3.8450 mL | |
20 mM | 0.1154 mL | 0.5768 mL | 1.1535 mL | 2.8838 mL | |
25 mM | 0.0923 mL | 0.4614 mL | 0.9228 mL | 2.3070 mL | |
30 mM | 0.0769 mL | 0.3845 mL | 0.7690 mL | 1.9225 mL | |
40 mM | 0.0577 mL | 0.2884 mL | 0.5768 mL | 1.4419 mL | |
50 mM | 0.0461 mL | 0.2307 mL | 0.4614 mL | 1.1535 mL | |
60 mM | 0.0385 mL | 0.1923 mL | 0.3845 mL | 0.9613 mL | |
80 mM | 0.0288 mL | 0.1442 mL | 0.2884 mL | 0.7209 mL | |
100 mM | 0.0231 mL | 0.1154 mL | 0.2307 mL | 0.5768 mL |