OPPA01903 | IL 18 Protein Biotrend

Cat# OPPA01903

Size : 2ug

Contact local distributor :

Phone : +1 850 650 7790

Brand : Aviva Systems Biology

Contact local distributor :

Phone : +1 850 650 7790

Datasheets/Manuals	Printable datasheet for OPPA01903

Product Info
Predicted Species Reactivity	Human
Product Format	Interleukin -18 His-Tag protein is supplied in 1xPBS, 50% glycerol. Physical appearance: Sterile Filtered clear solution.
Host	E. Coli
::	Product Introduction: IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. Product Description: Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 157 amino acids fragment (37-193) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL-18 His is purified by proprietary chromatographic techniques.
Reconstitution and Storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
Purity	Greater than 95.0% as determined by SDS-PAGE.

Gene Symbol	IL18
Alias Symbols	IGIF, IL-18, IL-1g, IL1F4
NCBI Gene Id	3606
Protein Name	Interleukin-18
Description of Target	Recombinant Human Interleukin-18 His Tag
Uniprot ID	Q14116
Protein Accession #	NP_001553.1
Protein Size (# AA)	Recombinant

Protein interactions

Name	# of Products
CASP1	98
CASP3	324
CASP4	79
IL18BP	5
IL18R1	15
IL18RAP	14
IL1RL2	5

Biological pathways

Name	# of Products
Angiogenesis	366
Cell-cell signaling	763
Chemokine biosynthetic process	5
Granulocyte macrophage colony-stimulating factor biosynthetic process	5
Interferon-gamma biosynthetic process	23
Interleukin-13 biosynthetic process	6
Interleukin-2 biosynthetic process	5
Positive regulation of activated T cell proliferation	123
Positive regulation of granulocyte macrophage colony-stimulating factor production	23
Positive regulation of inflammatory response	172
Positive regulation of interferon-gamma production	108
Positive regulation of interleukin-17 production	72
Positive regulation of natural killer cell proliferation	23
Positive regulation of NK T cell proliferation	16
Positive regulation of tissue remodeling	50
Regulation of cell adhesion	64
Sleep	11
T-helper 1 type immune response	37
Type 2 immune response	21

Biological process

Name	# of Products
Angiogenesis	196
Cell-cell signaling	235
Cellular response to cAMP	28
Cellular response to hydrogen peroxide	38
Cellular response to interferon-gamma	26
Cellular response to mechanical stimulus	62
Cellular response to organic cyclic compound	58
Cellular response to parathyroid hormone stimulus	6
Cellular response to peptide hormone stimulus	16
Cellular response to tumor necrosis factor	39
Chemokine biosynthetic process	1
Detection of mechanical stimulus involved in sensory perception of pain	7
Digestive tract morphogenesis	23
Granulocyte macrophage colony-stimulating factor biosynthetic process	1
Immune response	404
Inflammatory response	339
Interferon-gamma biosynthetic process	8
Interleukin-13 biosynthetic process	2
Interleukin-2 biosynthetic process	2
Lipopolysaccharide-mediated signaling pathway	48
Lung development	105
MAPK cascade	105
Osteoblast differentiation	57
Positive regulation of activated T cell proliferation	45
Positive regulation of chemokine production	34
Positive regulation of collagen biosynthetic process	29
Positive regulation of gene expression	160
Positive regulation of granulocyte macrophage colony-stimulating factor production	13
Positive regulation of inflammatory response	57
Positive regulation of interferon-gamma production	61
Positive regulation of interleukin-1 beta production	6
Positive regulation of interleukin-17 production	27
Positive regulation of interleukin-8 production	33
Positive regulation of male germ cell proliferation	3
Positive regulation of natural killer cell proliferation	14
Positive regulation of neuron apoptosis	53
Positive regulation of NK T cell proliferation	8
Positive regulation of superoxide anion generation	6
Positive regulation of tissue remodeling	6
Positive regulation of tumor necrosis factor production	64
Positive regulation of vascular permeability	16
Regulation of blood vessel remodeling	3
Regulation of cell adhesion	41
Response to cold	31
Response to hyperoxia	20
Response to hypoxia	205
Response to radiation	32
Sleep	21
T-helper 1 type immune response	14
Type 2 immune response	3

Cellular components

Name	# of Products
Apical plasma membrane	173
Cytoplasm	4549
Cytosol	1868
Extracellular region	1573
Extracellular space	884

Protein function

Name	# of Products
Cytokine activity	1104

Titration: 1.0 ug/ml
Positive Control: Hela Whole CellIL18 is supported by BioGPS gene expression data to be expressed in HeLa" data-size="300x300" class="product-image-wrapper cover">

IL18 Antibody - C-terminal region (ARP60740_P050)
Catalog #: ARP60740_P050

Species Tested: Human

Application: WB

Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
All lanes: Anti IL18 (OABB01190) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: Human Placenta Tissue Lysate at 50ug
Predicted bind size: 22 kDa
Observed bind size: 22 kDa" data-size="300x300" class="product-image-wrapper cover">

IL18 Antibody (OABB01190)
Catalog #: OABB01190

Clone: Polyclonal

Species Tested: Human

Application: Immunohistochemistry|Western blot

Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Size: 100UG
IL18 ELISA Kit (Human) : 96 Wells (OKEH00105)
Catalog #: OKEH00105

Application: Enzyme-linked Immunosorbent assay-Sandwich

Kit Range: 15.6-1000pg/mL

Sensitivity: 10 pg/mL

Size: 96T
IL18 Antibody (OAAN00220)
Catalog #: OAAN00220

Conjugation: Unconjugated

Application: WB, IHC

Format: Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
IL18 ELISA Kit (Mouse) (OKEH04042)
Catalog #: OKEH04042

Application: Enzyme-linked Immunosorbent assay-Sandwich

Kit Range: 15.6-1000pg/mL

Sensitivity: 7.87 pg/mL

Size: 96T

IL 18 Protein

Cat# OPPA01903

Contact local distributor :

Brand : Aviva Systems Biology

Contact local distributor :

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