IL 18 Protein

Cat# OPPA00534

Size : 5ug

Brand : Aviva Systems Biology

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Datasheets/ManualsPrintable datasheet for OPPA00534
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized 0.5x PBS (pH 7.3)
HostE. Coli
Reconstitution and StorageIt is recommended to reconstitute the lyophilized Interleukin 18 in sterile 18M-omega-cm H2O not less than 100 ug/mL, which can then be further diluted to other aqueous solutions. Lyophilized Interleukin 18 although stable at room temperature for 3 weeks, should be stored dessicated below -18°C. Upon reconstitution IL18 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage, it is recommended to add a carrier protein (0.1% HSA and BSA). Please prevent freeze/thaw cycles.
PurificationPurified by proprietary chromatographic techniques.
Concentration1 mg/ml (prior to lyophilization)
PurityGreater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Biological ActivityThe ED50 as determined by the dose-dependant stimulation of the IFN-g by human PBMC co-stimulated with IL-12 was found to be 5 ng/ml corresponding to a Specific Activity of 200,000 IU/mg.
Gene SymbolIL18
Alias SymbolsIGIF, IL-18, IL-1g, IL1F4
NCBI Gene Id3606
Protein NameInterleukin-18
Description of TargetIL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids.
Uniprot IDQ14116
Protein Accession #NP_001553.1
Protein Size (# AA)Recombinant
Molecular Weight18 kDa

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