IKBKB Antibody - N-terminal region : HRP
Cat# ARP32665_P050-HRP
Size : 100ul
Brand : Aviva Systems Biology
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Phone : +1 850 650 7790
IKBKB Antibody - N-terminal region : HRP (ARP32665_P050-HRP)
| Datasheets/Manuals | Printable datasheet for anti-IKBKB (ARP32665_P050-HRP) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
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| Product Format | Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | HRP: Horseradish Peroxidase |
| Application | WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human IKBKB |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: CITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNN |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-IKBKB (ARP32665_P050-HRP) antibody is Catalog # AAP32665 (Previous Catalog # AAPP03675) |
| Sample Type Confirmation | IKBKB is strongly supported by BioGPS gene expression data to be expressed in 721_B |
| Subunit | beta |
| Reference | Hu,W., (2008) Biochem. J. 412 (1), 35-43 |
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| Gene Symbol | IKBKB |
| Gene Full Name | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Alias Symbols | IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, IKK-beta |
| NCBI Gene Id | 3551 |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Description of Target | NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-203 AL708460.1 9-211 204-3077 AF080158.1 170-3043 3078-3916 AK023193.1 1980-2818 |
| Uniprot ID | O14920 |
| Protein Accession # | NP_001547 |
| Nucleotide Accession # | NM_001556 |
| Protein Size (# AA) | 756 |
| Molecular Weight | 86kDa |
| Protein Interactions | BCL10; IKBKG; UBC; Snap23; RELA; NFKBIA; MTOR; RPTOR; ROCK1; IKBKB; CDC37; KEAP1; MAP3K7; FLNC; NGFR; EGLN3; SASH1; COPS5; COPS3; PPP1CA; TPX2; TNFRSF1A; AURKA; PRKCQ; MAP3K1; TFAP2C; NLRC5; PYCARD; TAB2; IKBKE; MAP3K14; CHUK; HSPB1; PRKCE; NAA20; TRAF3IP |
