Human TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TNFRSF1B
Gene ID:	7133
Uniprot ID:	TNR1B_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylated.mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Protein Name	Tumor Necrosis Factor Receptor Superfamily Member 1b Tumor Necrosis Factor Receptor 2 Tnf-R2 Tumor Necrosis Factor Receptor Type Ii Tnf-Rii Tnfr-Ii P75 P80 Tnf-Alpha Receptor Cd Antigen Cd120b Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 Tbp-2 Tbpii
Database Links	Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Tumor Necrosis Factor-Binding Protein 2: Secreted
Alternative ELISA Names	Tumor Necrosis Factor Receptor Superfamily Member 1b ELISA kit Tumor Necrosis Factor Receptor 2 ELISA kit Tnf-R2 ELISA kit Tumor Necrosis Factor Receptor Type Ii ELISA kit Tnf-Rii ELISA kit Tnfr-Ii ELISA kit P75 ELISA kit P80 Tnf-Alpha Receptor ELISA kit Cd Antigen Cd120b ELISA kit Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 ELISA kit Tbp-2 ELISA kit Tbpii ELISA kit TNFRSF1B ELISA kit TNFBR ELISA kit TNFR2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance