Specifications

Product Data
Format	8x12 divisible strips
Assay Type	Sandwich ELISA kit of Quantitative Detection for Human PROS1
Assay Length	3.5 hours incubations; 1 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	312pg/ml-20000pg/ml
Specificity	This kit is used for quantitative detection of Human PROS1
Sensitivity	<50pg/ml
Reactivities	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Components	96-well plate precoated with anti- human PROS1 antibody | 1 Lyophilized recombinant human PROS1 standard | 100ng/tube×2 Biotinylated anti- human PROS1 antibody | 100μl(dilution 1:100) Avidin-Biotin-Peroxidase Complex (ABC) | 100μl(dilution 1:100) Sample diluent buffer | 30 ml Antibody diluent buffer | 12ml ABC diluent buffer | 12ml TMB color developing agent | 10ml TMB stop solution | 10ml Plate Sealers 4 x Wash Buffer (25x) | 20ml
Background	This PROS1 gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. This gene is mapped to 3q11.1. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4bbinding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
Gene Symbol	PROS1
Gene ID	5627