Human IL-21 Antibody : Biotin
Cat# OASB01355
Size : 0.5mg
Brand : Aviva Systems Biology
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Human IL-21 Antibody : Biotin (OASB01355)
| Datasheets/Manuals | Printable datasheet for Human IL-21 Antibody : Biotin (OASB01355) |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human |
| Clonality | Monoclonal |
| Clone | SB134f |
| Isotype | IgG2a |
| Host | Mouse |
| Conjugation | Biotin |
| Additional Information | Description: Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | E. coli-expressed human IL-21 |
| Concentration | 0.5 mg/mL |
| Specificity | IL-21 |
| Characterization | To ensure acceptable performance, each batch of product is tested by ELISA to conform tocharacteristics of a standard reference reagent. |
| Dilution | #N/A |
| Application Info | Enzyme-Linked Immunosorbent Assay (ELISA) |
| Storage | - The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of100mM borate buffered saline, pH 8.2; store at 2- 8 C - The biotin (BIOT) conjugate is supplied as 0.5mg labeled antibody in 1.0mL ofPBS/NaN3. Store at 2- 8 C - Reagents are stable for the period shown on the label if stored as directed. |
| Reference | 1) Rosanne Spolski and Warren J. Leonard (2008). Annu Rev Immunol 29:57- 79 2) Ettinger, R., et al. (2005). J. Immunol. 175:7867- 7879 3) Kuchen, S., et al. (2007). J. Immunol. 179:5886- 5896 4) Parrish- Novak, J. et al. (2000). Nature. 408:57- 63 5) Aviva Systems Biology (2009) unpublished observations. |
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| Gene Symbol | IL21 |
| Alias Symbols | Za11, IL-21, CVID11 |
| NCBI Gene Id | 59067 |
| Protein Name | interleukin-21 |
| Description of Target | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Uniprot ID | Q9HBE4 |
| Protein Accession # | NP_001193935.1 |
| Nucleotide Accession # | NM_001207006.2 |
