General Info
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 7.9 pg/mL |
| Detection Limit: | 156-1000 pg/ml |
| Short Description: | This GDNF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Conjugation: | Biotin |
| Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: | 4 hours |
| Detection: | Colorimetric |
Information
| Gene Symbol: | GDNF |
| Gene ID: | 2668 |
| Uniprot ID: | GDNF_HUMAN |
| Sample Type: | serum, plasma and cell culture supernates |
Description
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Post Translational Modifications | |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. |
| Protein Name | Glial Cell Line-Derived Neurotrophic FactorHgdnfAstrocyte-Derived Trophic FactorAtf |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Glial Cell Line-Derived Neurotrophic Factor ELISA kitHgdnf ELISA kitAstrocyte-Derived Trophic Factor ELISA kitAtf ELISA kitGDNF ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance