Human CLASP2 (CLIP-associating protein 2) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	CLASP2
Gene ID:	23122
Uniprot ID:	CLAP2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Brain-specific.
Post Translational Modifications	Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
Function	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Protein Name	Clip-Associating Protein 2 Cytoplasmic Linker-Associated Protein 2 Protein Orbit Homolog 2 Horbit2
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-428890 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-9648025
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Chromosome Centromere Kinetochore Spindle Golgi Apparatus Trans-Golgi Network Cell Membrane Cell Projection Ruffle Membrane Localizes To Microtubule Plus Ends Localizes To Centrosomes Kinetochores And The Mitotic Spindle From Prometaphase Subsequently Localizes To The Spindle Midzone From Anaphase And To The Midbody From Telophase In Migrating Cells Localizes To The Plus Ends Of Microtubules Within The Cell Body And To The Entire Microtubule Lattice Within The Lamella Localizes To The Cell Cortex And This Requires Erc1 And Phldb2 The Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane
Alternative ELISA Names	Clip-Associating Protein 2 ELISA kit Cytoplasmic Linker-Associated Protein 2 ELISA kit Protein Orbit Homolog 2 ELISA kit Horbit2 ELISA kit CLASP2 ELISA kit KIAA0627 ELISA kit
output

Information sourced from Uniprot.org

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