Human AMH (AMH) Sandwich ELISA Kit

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	AMH
Gene ID:	268
Uniprot ID:	MIS_HUMAN
Sample Type:	serum, plasma and cell culture supernates

Tissue Specificity	In ovaries, AMH is detected in granulosa cells of early growing follicles.
Post Translational Modifications	Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
Function	Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Protein Name	Muellerian-Inhibiting Factor Anti-Muellerian Hormone Amh Muellerian-Inhibiting Substance Mis
Database Links	Reactome: R-HSA-201451 Reactome: R-HSA-9690406
Cellular Localisation	Secreted
Alternative ELISA Names	Muellerian-Inhibiting Factor ELISA kit Anti-Muellerian Hormone ELISA kit Amh ELISA kit Muellerian-Inhibiting Substance ELISA kit Mis ELISA kit AMH ELISA kit MIF ELISA kit
output

Information sourced from Uniprot.org

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