Reagents and instruments for immunology, cell biology and molecular biology.
 
> H 1152 dihydrochloride [451462-58-1]

H 1152 dihydrochloride [451462-58-1]

Print Print
Please log in

Cat# VD-AM-0102-5mg

Size : 5mg

Brand : VDM Biochemicals

Contact local distributor :


Phone : +1 850 650 7790

Product Specification

  • Appearance
    :

    White to off-white solid.

  • CAS Number
    :

    451462-58-1

  • Cat.number
    :

    VD-AM-0102

  • Formula
    :

    C16H21N3O2S.2HCl

  • MW
    :

    392.34

  • Purity
    :

    ≥98%

  • Solubility
    :

    Soluble to 100 mM in H2O and to 50 mM in DMSO

  • Storage
    :

    +4°C.

  • Synonyms
    :

    Not available.

  • Size
    :

    1mg, 5mg

SKU: VD-AM-0102 Categories: Angiogenesis and Metastasis, Cancer

Description

H 1152 dihydrochloride (CAS 451462-58-1) is a Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea-pig aorta (IC50 = 190 nM) and displays proerectile effects in rats.

1. Shum et al (2003) Br.J.Pharmacol. 139 1449.
2. Teixeira et al (2005) J.Pharmacol.Exp.Ther. 315 155.
3. Tamura et al (2005) Biochim.Biophys.Acta 1754 245.