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Dimethyl sulfoxide [67-68-5]
Cat# T0341-100mL
Size : 100mL
Brand : TargetMol
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Dimethyl sulfoxide
Catalog No. T0341 CAS 67-68-5
Synonyms: Methyl Sulfoxide, DMSO
Dimethyl sulfoxide (DMSO) is a commonly used solvent to dissolve polar and non-polar compounds. Dimethyl sulfoxide has been widely used for masterbatch preparation of compounds in biological experiments. Dimethyl sulfoxide has bacteriostatic activity.
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Dimethyl sulfoxide, CAS 67-68-5
| Description | Dimethyl sulfoxide (DMSO) is a commonly used solvent to dissolve polar and non-polar compounds. Dimethyl sulfoxide has been widely used for masterbatch preparation of compounds in biological experiments. Dimethyl sulfoxide has bacteriostatic activity. |
| In vitro | METHODS: Human colorectal cancer cells HCT-116 and SW-480 were treated with Dimethyl sulfoxide (0.1%-1.5%) for 24 h, and cell viability was measured by MTT. RESULTS: Dimethyl sulfoxide showed a dose-dependent effect on cell proliferation. Cells treated with 1.5% Dimethyl sulfoxide showed about 10% reduction in cell growth. [1] |
| In vivo | METHODS: To detect toxicity, Dimethyl sulfoxide (10%-100%) was administered to Swiss mice by single intraperitoneal injection for five days. RESULTS: The LD50 increased with decreasing concentration and the LD50 values for 10%, 25%, 50%, 75%, and 100% Dimethyl sulfoxide were >10.1, 15.4, 13.3, 11.9, and 10.9 g/kg, respectively. [2] |
| Synonyms | Methyl Sulfoxide, DMSO |
| Molecular Weight | 78.13 |
| Formula | C2H6OS |
| CAS No. | 67-68-5 |
Storage
References and Literature
1. Tunçer S, et al. Low dose dimethyl sulfoxide driven gross molecular changes have the potential to interfere with various cellular processes. Sci Rep. 2018 Oct 4;8(1):14828. 2. Worthley EG, et al. The toxicity of four concentrations of DMSO. Toxicol Appl Pharmacol. 1969 Sep;15(2):275-81.
Citations
1. Liang C, Yu X, Xiong N, et al. Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway. Frontiers in oncology. 2020, 10. 2. Guo L, Wu Z. FOXM1‐mediated NUF2 expression confers temozolomide resistance to human glioma cells by regulating autophagy via the PI3K/AKT/mTOR signaling pathway. Neuropathology. 2022 3. Yu Z, Niu P, Su Z, et al.Role of Atractylenolide I in Cerebral Ischemia Reperfusion Injury.Revista Brasileira de Farmacognosia.2023: 1-10. 4. Chen L, Ye T, Wang X, et al.Decoction on Major Depressive Disorder based on Network Pharmacology and Molecular Docking.Combinatorial Chemistry & High Throughput Screening.2023, 26(9): 1701-1728.
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Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Dimethyl sulfoxide 67-68-5 Microbiology/Virology Others Antibacterial solvent Methyl Sulfoxide bacteriostatic Bacterial Inhibitor DMSO inhibit anti-freezing anti-inflammatory aprotic inhibitor