ARP2/ARP3 Polyclonal Antibody, AbBy Fluor® 594 Conjugated

Cat# bs-12524R-BF594-20ul

Size : 20ul

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ARP2/ARP3 Polyclonal Antibody, AbBy Fluor® 594 Conjugated


  • WB
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)


  • Mouse
  • Xenopus laevis

Predicted Reactivity

  • Human
  • Rat
  • Cow
  • Pig
  • Chicken
Catalog # bs-12524R-BF594
Product Name ARP2/ARP3 Polyclonal Antibody, AbBy Fluor® 594 Conjugated
Applications WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity Mouse, Xenopus laevis
Predicted Reactivity Human, Rat, Cow, Pig, Chicken
Conjugation AbBy Fluor® 594
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ARP2/ARP3
Immunogen Range 301-394/394
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID 10097
Subcellular location Cytoplasm
Synonyms Actin like protein 2; Actin related protein 2; Actin-like protein 2; ACTIN-RELATED PROTEIN 2; ACTR2; ARP2 actin related protein 2 homolog yeast; ARP2; ARP2/3 COMPLEX; ARP2_HUMAN; OTTHUMP00000159937; OTTHUMP00000202270.
Background Actin polymerization is required for a variety of cell functions, including chemotaxis, cell migration, cell adhesion, and platelet activation. Cells trigger actin polymerization through either the de novo nucleation of filaments from monomeric actin, the severing of existing filaments to create uncapped barbed ends, or the uncapping of existing barbed ends. The nucleation of actin is a rate-limiting and unfavorable reaction in actin polymerization and therefore requires the involvement of the Arp2/3 complex, which helps create new filaments and promotes the end-to-side cross-linking of actin filaments into the branching meshwork. The Arp2/3 complex consists of the actin-related proteins Arp2 and Arp3, and various other accessory proteins. The Arp2/3 complex promotes actin nucleation by binding the pointed end of actin filaments, or by associating with the side of an existing filament, and nucleates growth in the barbed direction. In addition, the Arp2/3 complex also mediates actin cytoskeletal outgrowths that are regulated by the Rho family of small GTPases. In response to GTP-binding Cdc42, the Arp2/3 complex binds the Cdc42 substrates, namely the WASP proteins, and initiates the formation of lamellipodia and filopodia.
Application Dilution
WB 1:300-5000
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200