General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-STAT2 (550-706) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | STAT2 |
| Gene ID: | 6773 |
| Uniprot ID: | STAT2_HUMAN |
| Immunogen Region: | 550-706 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-706 of human STAT2 (NP_005410.1). |
| Immunogen Sequence: | KLPFWTWLDKILELVHDHLK DLWNDGRIMGFVSRSQERRL LKKTMSGTFLLRFSESSEGG ITCSWVEHQDDDKVLIYSVQ PYTKEVLQSLPLTEIIRHYQ LLTEENIPENPLRFLYPRIP RDEAFGCYYQEKVNLQERRK YLKHRLIVVSNRQVDEL |
Description
| Post Translational Modifications | Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response. 'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation. (Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22. |
| Function | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. |
| Protein Name | Signal Transducer And Activator Of Transcription 2P113 |
| Database Links | Reactome: R-HSA-8854691Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9679191Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta |
| Alternative Antibody Names | Anti-Signal Transducer And Activator Of Transcription 2 antibodyAnti-P113 antibodyAnti-STAT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance