Anti-NAMPT antibody (200-300) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.68-0.70 µg/µl
Dilution Range:	WB: 1:500 DB: 1:4, 000 ELISA: 1:4, 000 IP: 1:150 IHC: 1:50-1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	NAMPT
Gene ID:	10135
Uniprot ID:	NAMPT_HUMAN
Immunogen Region:	200-300
Immunogen:	N-epitope synthetic peptide taken within amino acid region 200-300 on human Visfatin protein.

Tissue Specificity	Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Function	Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Protein Name	Nicotinamide Phosphoribosyltransferase Namprtase Nampt Pre-B-Cell Colony-Enhancing Factor 1 Pre-B Cell-Enhancing Factor Visfatin
Database Links	Reactome: R-HSA-1368108 Reactome: R-HSA-197264 Reactome: R-HSA-9768919
Cellular Localisation	Nucleus Cytoplasm Secreted Under Non-Inflammatory Conditions Visfatin Predominantly Exhibits A Granular Pattern Within The Nucleus Secreted By Endothelial Cells Upon Il-1beta Stimulation Abundantly Secreted In Milk Reaching 100-Fold Higher Concentrations Compared To Maternal Serum
Alternative Antibody Names	Anti-Nicotinamide Phosphoribosyltransferase antibody Anti-Namprtase antibody Anti-Nampt antibody Anti-Pre-B-Cell Colony-Enhancing Factor 1 antibody Anti-Pre-B Cell-Enhancing Factor antibody Anti-Visfatin antibody Anti-NAMPT antibody Anti-PBEF antibody Anti-PBEF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance