Anti-HSP47 SERPINH1 Antibody (Monoclonal, M16.10A1)

Cat# M03050

Size : 200ug

Brand : Boster Immunoleader

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Phone : +1 850 650 7790

  • M03050_1 WB anti hsp47 antibody monoclonal m16 10a1
  • M03050_2 IHC anti hsp47 antibody monoclonal m16 10a1
  • M03050_3 IHC anti hsp47 antibody monoclonal m16 10a1

Product Info Summary

SKU: M03050
Size: 200μg/vial
Reactive Species: Human, Mouse, Rat
Host: Mouse
Application: IHC, WB

Product info

Product Name

Anti-HSP47 SERPINH1 Antibody (Monoclonal, M16.10A1)

View all Hsp47 Antibodies

SKU/Catalog Number

M03050

Size

200μg/vial

Form

Liquid

Description

Boster Bio Anti-HSP47 SERPINH1 Antibody (Monoclonal, M16.10A1) catalog # M03050. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Cite This Product

Anti-HSP47 SERPINH1 Antibody (Monoclonal, M16.10A1) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03050)

Host

Mouse

Contents

Each vial contains 50% glycerol and 0.09% sodium azide.

Clonality

Monoclonal

Clone Number

M16.10A1

Immunogen

Native rat HSP47.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M03050 is reactive to SERPINH1 in Human, Mouse, Rat

Applications

M03050 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

46.441kDa

Background of Hsp47

Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay dilution & Images

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:1, 000, ECL, Human, Mouse, Rat
IHC, 1:50, Human, Mouse, Rat

Validation Images & Assay Conditions

Protein Target Info & Infographic

Gene/Protein Information For SERPINH1 (Source: Uniprot.org, NCBI)

Uniprot ID

P50454

Gene ID

871

Gene Name

SERPINH1

Full Name

Serpin H1

Weight

46.441kDa

Superfamily

serpin family

Alternative Names

(collagen binding protein 1); Arsenic-transactivated protein 3; AsTP3; BERF-1; CBP1; CBP2; CBP2RA-A47; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; colligen; Colligin; colligin-1; colligin-2; gp46; HSP47; HSP47serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47); member 1, (collagen binding protein 1); member 2; member 2, (collagen-binding protein 2); OI10; PPROM; proliferation-inducing gene 14; RA-A47; rheumatoid arthritis antigen A-47,47 kDa heat shock protein; Rheumatoid arthritis-related antigen RA-A47; serine (or cysteine) proteinase inhibit SERPINH1 AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46 serpin family H member 1 serpin H1|47 kDa heat shock protein|arsenic-transactivated protein 3|cell proliferation-inducing gene 14 protein|collagen binding protein 1|colligin-1|colligin-2|rheumatoid arthritis antigen A-47|rheumatoid arthritis-related antigen RA-A47|serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)|serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2)|serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".