Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CYP19A1
Gene ID:	1588
Uniprot ID:	CP19A_HUMAN
Immunogen Region:	1-180
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human Aromatase (CYP19A1) (NP_000094.2).
Immunogen Sequence:	MVLEMLNPIHYNITSIVPEA MPAATMPVLLLTGLFLLVWN YEGTSSIPGPGYCMGIGPLI SHGRFLWMGIGSACNYYNRV YGEFMRVWISGEETLIISKS SSMFHIMKHNHYSSRFGSKL GLQCIGMHEKGIIFNNNPEL WKTTRPFFMKALSGPGLVRM VTVCAESLKTHLDRLEEVTN

Tissue Specificity	Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Post Translational Modifications	Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).
Function	A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase).
Protein Name	Aromatase Cypxix Cytochrome P-450arom Cytochrome P450 19a1 Estrogen Synthase
Database Links	Reactome: R-HSA-193144 Reactome: R-HSA-211976 Reactome: R-HSA-5579030
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Microsome Membrane
Alternative Antibody Names	Anti-Aromatase antibody Anti-Cypxix antibody Anti-Cytochrome P-450arom antibody Anti-Cytochrome P450 19a1 antibody Anti-Estrogen Synthase antibody Anti-CYP19A1 antibody Anti-ARO1 antibody Anti-CYAR antibody Anti-CYP19 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance