General Info
| Host: | Mouse |
| Applications: | FC/IHC-F/ELISA/IF |
| Reactivity: | Human/Pig/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD146 is suitable for use in Flow Cytometry, Immunohistochemistry, ELISA and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | OJ79c |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 0.09% sodium azide |
| Concentration: | 1.0 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | Recombinant human MUC18 (D1-D5) Fc protein. |
Description
| Background | Mouse anti Human CD146 antibody, clone OJ79c recognizes human Cell surface glycoprotein MUC18, also known as CD146, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule (MCAM) or S-endo 1 endothelial-associated antigen. CD146 is a 646 amino acid single pass type 1 transmembrane glycoprotein with a calculated molecular mass of ~72 kDa. However due to extensive N-linked glycosylation CD146 migrates in polyacrylamide gels with an apparent molecular mass of ~118 kDa. CD146 is a member of the immunoglobulin superfamily bearing 2 V-type Ig-like and 3 C-type Ig-like domains. CD146 is expressed by all endothelial cells and by melanoma cells and appears to act as an adhesion molecule (UniProt: P43121). Expression in melanoma may be linked to tumor progression (Lehmann et al. 1989).Mouse anti Human CD146 antibody, clone OJ79c is highly expressed on pericytes and has been utilized for the identification of perivascular mesenchymal precursor cells from cardiac muscle using flow cytometry (Chen et al. 2014). |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance