General Info
Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Chromobox protein homolog 5 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | CBX5 |
Gene ID: | 23468 |
Uniprot ID: | CBX5_HUMAN |
Immunogen Region: | 41-90 aa |
Specificity: | HP1 Alpha Polyclonal Antibody detects endogenous levels of HP1 Alpha protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human CBX5 at the amino acid range 41-90 |
Description
Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Protein Name | Chromobox Protein Homolog 5Antigen P25Heterochromatin Protein 1 Homolog AlphaHp1 Alpha |
Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8953750Reactome: R-HSA-983231 |
Cellular Localisation | NucleusChromosomeCentromereColocalizes With Hnrnpu In The NucleusComponent Of Centromeric And Pericentromeric HeterochromatinAssociates With Chromosomes During MitosisAssociates Specifically With Chromatin During Metaphase And AnaphaseLocalizes To Sites Of Dna Damage |
Alternative Antibody Names | Anti-Chromobox Protein Homolog 5 antibodyAnti-Antigen P25 antibodyAnti-Heterochromatin Protein 1 Homolog Alpha antibodyAnti-Hp1 Alpha antibodyAnti-CBX5 antibodyAnti-HP1A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance