General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ALAS2 (50-320) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ALAS2 |
| Gene ID: | 212 |
| Uniprot ID: | HEM0_HUMAN |
| Immunogen Region: | 50-320 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human ALAS2 (NP_001033057.1). |
| Immunogen Sequence: | VKTHQFLFGIGRCPILATQG PNCSQIHLKATKAGGDSPSW AKGHCPFMLSELQDGKSKIV QKAAPEVQEDVKAFKTGNYV FSYDQFFRDKIMEKKQDHTY RVFKTVNRWADAYPFAQHFS EASVASKDVSVWCSNDYLGM SRHPQVLQATQETLQRHGAG AGGTRNISGTSKFHVELEQE LAELHQKDSALLFSSCFVAN DSTLFTLAKILPGCEIYSDA GNHASMIQGIRNSGAAKFV |
Description
| Tissue Specificity | Isoform 1: Erythroid-specific. Isoform 2: Erythroid-specific. Isoform 3: Erythroid-specific. Isoform 4: Erythroid-specific. |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Contributes significantly to heme formation during erythropoiesis. Isoform 3: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 75-85% of isoform 1 activity. Isoform 4: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 65-75% of isoform 1 activity. |
| Protein Name | 5-Aminolevulinate Synthase - Erythroid-Specific - MitochondrialAlas-E5-Aminolevulinic Acid Synthase 2Delta-Ala Synthase 2Delta-Aminolevulinate Synthase 2 |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner MembraneIsoform 4: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Erythroid-Specific - Mitochondrial antibodyAnti-Alas-E antibodyAnti-5-Aminolevulinic Acid Synthase 2 antibodyAnti-Delta-Ala Synthase 2 antibodyAnti-Delta-Aminolevulinate Synthase 2 antibodyAnti-ALAS2 antibodyAnti-ALASE antibodyAnti-ASB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance