Specifications

Product Data
Clone Name	N/A
Recommended Dilution	WB: 1:5000-10000
Reactivities	Human, Mouse, Rat, Chicken, Cow
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH.
Formulation	Rabbit antiserum
Concentration	lot specific
Purification	Rabbit antiserum
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Gene Name	crystallin alpha B
Database Link	NP_001876 Entrez Gene 12955 MouseEntrez Gene 25420 RatEntrez Gene 1410 Human UniProt ID P02511
Background	The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27 . Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its phosphorylated state and may serve a structural control function and play a role in protein maintenance . In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases . Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions .
Synonyms	CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2
Note	Detects ~22kDa. Does not cross-react with aA-crystallin.
Reference Data