Reagents and instruments for immunology, cell biology and molecular biology.
 
> 1-Ethynylnaphthalene [15727-65-8]

1-Ethynylnaphthalene [15727-65-8]

Print Print
Please log in

Cat# HY-111430-1ml

Size : 10mM/1mL

Brand : MedChemExpress

Contact local distributor :


Phone : +1 850 650 7790

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. 1-Ethynylnaphthalene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

1-Ethynylnaphthalene Chemical Structure

CAS No. : 15727-65-8

*

This product is a controlled substance and not for sale in your territory.

1-Ethynylnaphthalene Related Antibodies

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. 1-Ethynylnaphthalene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

P450 1B1
In Vitro

1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Ethynylnaphthalene Related Antibodies

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

  • [1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.  [Content Brief]

  • [1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.5707 mL 32.8537 mL 65.7073 mL 164.2683 mL
5 mM 1.3141 mL 6.5707 mL 13.1415 mL 32.8537 mL
10 mM 0.6571 mL 3.2854 mL 6.5707 mL 16.4268 mL
15 mM 0.4380 mL 2.1902 mL 4.3805 mL 10.9512 mL
20 mM 0.3285 mL 1.6427 mL 3.2854 mL 8.2134 mL
25 mM 0.2628 mL 1.3141 mL 2.6283 mL 6.5707 mL
30 mM 0.2190 mL 1.0951 mL 2.1902 mL 5.4756 mL
40 mM 0.1643 mL 0.8213 mL 1.6427 mL 4.1067 mL
50 mM 0.1314 mL 0.6571 mL 1.3141 mL 3.2854 mL
60 mM 0.1095 mL 0.5476 mL 1.0951 mL 2.7378 mL
80 mM 0.0821 mL 0.4107 mL 0.8213 mL 2.0534 mL
100 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Metabolic Enzyme/Protease
  • Cytochrome P450
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Ethynylnaphthalene15727-65-8Cytochrome P450CYPsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Bulk Inquiry

Inquiry Information

Product Name:
1-Ethynylnaphthalene
Cat. No.:
HY-111430
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

You might also be interested by the following products:



Cat#
Description
Cond.
Price Bef. VAT
ELH-CRP-1
Human CRP ELISA
 1PlateKit