Usp51 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN318810LP

Usp51 - mouse gene knockout kit via CRISPR, HDR mediated



HDR-mediated knockout kit validation

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Specifications

Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA Luciferase-Puro
Symbol Usp51
Locus ID 635253
Components

KN318810G1, Usp51 gRNA vector 1 in pCas-Guide CRISPR vector

KN318810G2, Usp51 gRNA vector 2 in pCas-Guide CRISPR vector

KN318810LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001137547
UniProt ID B1AY15
Synonyms AV136873
Summary Deubiquitinates histone H2A at 'Lys-13' and 'Lys-15' and regulates DNA damage response. USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 foci.[UniProtKB/Swiss-Prot Function]

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