Suv39h2 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN317006BN
Suv39h2 - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
| Donor DNA | mBFP-Neo |
| Symbol | Suv39h2 |
| Locus ID | 64707 |
| Components | KN317006G1, Suv39h2 gRNA vector 1 in pCas-Guide CRISPR vector KN317006G2, Suv39h2 gRNA vector 2 in pCas-Guide CRISPR vector KN317006BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_022724, NR_027509 |
| UniProt ID | Q9EQQ0 |
| Synonyms | 4930507K23Rik; AA536750; D030054H19Rik; D2Ertd544e; KMT1B |
| Summary | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN317006 | Suv39h2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN317006LP | Suv39h2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN317006RB | Suv39h2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN517006 | Suv39h2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA206493 | Suv39h2 CRISPRa kit - CRISPR gene activation of mouse suppressor of variegation 3-9 2 | 1 657,00 EUR |