Satb2 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN315311BN
Satb2 - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
| Donor DNA | mBFP-Neo |
| Symbol | Satb2 |
| Locus ID | 212712 |
| Components | KN315311G1, Satb2 gRNA vector 1 in pCas-Guide CRISPR vector KN315311G2, Satb2 gRNA vector 2 in pCas-Guide CRISPR vector KN315311BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_139146, NM_001358580, NM_001358581 |
| UniProt ID | Q8VI24 |
| Synonyms | mKIAA1034 |
| Summary | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN315311 | Satb2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN315311LP | Satb2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN315311RB | Satb2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN515311 | Satb2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA213099 | Satb2 CRISPRa kit - CRISPR gene activation of mouse special AT-rich sequence binding protein 2 | 1 657,00 EUR |