Ptpn11 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN314207RB
Ptpn11 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | Ptpn11 |
| Locus ID | 19247 |
| Components | KN314207G1, Ptpn11 gRNA vector 1 in pCas-Guide CRISPR vector KN314207G2, Ptpn11 gRNA vector 2 in pCas-Guide CRISPR vector KN314207RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_001109992, NM_011202 |
| UniProt ID | P35235 |
| Synonyms | 2700084A17Rik; AW536184; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp |
| Summary | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN314207 | Ptpn11 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN314207BN | Ptpn11 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN314207LP | Ptpn11 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN514207 | Ptpn11 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA203473 | Ptpn11 CRISPRa kit - CRISPR gene activation of mouse protein tyrosine phosphatase, non-receptor type 11 | 1 657,00 EUR |