Ppargc1a Mouse Gene Knockout Kit (CRISPR)
CAT#: KN313676LP
Ppargc1a - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
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Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
| Donor DNA | Luciferase-Puro |
| Symbol | Ppargc1a |
| Locus ID | 19017 |
| Components | KN313676G1, Ppargc1a gRNA vector 1 in pCas-Guide CRISPR vector KN313676G2, Ppargc1a gRNA vector 2 in pCas-Guide CRISPR vector KN313676LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_008904, NR_027710, NR_132764 |
| UniProt ID | O70343 |
| Synonyms | A830037N07Rik; ENSMUSG00000079510; Gm11133; PGC-1; Pgc-1alpha; Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1 |
| Summary | This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN313676 | Ppargc1a - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN313676BN | Ppargc1a - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN313676RB | Ppargc1a - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN513676 | Ppargc1a - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA203342 | Ppargc1a CRISPRa kit - CRISPR gene activation of mouse peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | 1 657,00 EUR |