Kras Mouse Gene Knockout Kit (CRISPR)
CAT#: KN308968LP
Kras - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
| Donor DNA | Luciferase-Puro |
| Symbol | Kras |
| Locus ID | 16653 |
| Components | KN308968G1, Kras gRNA vector 1 in pCas-Guide CRISPR vector KN308968G2, Kras gRNA vector 2 in pCas-Guide CRISPR vector KN308968LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_021284 |
| UniProt ID | P32883 |
| Synonyms | AI929937; c-K-ras; c-Ki-ras; K-Ras; K-ras; Ki-ras; Kras-2; Kras2; p21B; ras |
| Summary | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:6474169, PubMed:1352876). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN308968 | Kras - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN308968BN | Kras - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN308968RB | Kras - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN508968 | Kras - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA202362 | Kras CRISPRa kit - CRISPR gene activation of mouse Kirsten rat sarcoma viral oncogene homolog | 1 657,00 EUR |