Il6 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN308293RB
Il6 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | Il6 |
| Locus ID | 16193 |
| Components | KN308293G1, Il6 gRNA vector 1 in pCas-Guide CRISPR vector KN308293G2, Il6 gRNA vector 2 in pCas-Guide CRISPR vector KN308293RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_031168 |
| UniProt ID | P08505 |
| Synonyms | Il-6 |
| Summary | This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN308293 | Il6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN308293BN | Il6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN308293LP | Il6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN508293 | Il6 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA202149 | Il6 CRISPRa kit - CRISPR gene activation of mouse interleukin 6 | 1 657,00 EUR |