Erap1 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN305313RB
Erap1 - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | Erap1 |
| Locus ID | 80898 |
| Components | KN305313G1, Erap1 gRNA vector 1 in pCas-Guide CRISPR vector KN305313G2, Erap1 gRNA vector 2 in pCas-Guide CRISPR vector KN305313RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_030711 |
| UniProt ID | Q9EQH2 |
| Synonyms | Arts1; ERAAP; PILSA; PILSAP |
| Summary | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN305313 | Erap1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN305313BN | Erap1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN305313LP | Erap1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN505313 | Erap1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA211154 | Erap1 CRISPRa kit - CRISPR gene activation of mouse endoplasmic reticulum aminopeptidase 1 | 1 657,00 EUR |