Dusp6 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN304882LP
Dusp6 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
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Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
| Donor DNA | Luciferase-Puro |
| Symbol | Dusp6 |
| Locus ID | 67603 |
| Components | KN304882G1, Dusp6 gRNA vector 1 in pCas-Guide CRISPR vector KN304882G2, Dusp6 gRNA vector 2 in pCas-Guide CRISPR vector KN304882LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_026268 |
| UniProt ID | Q9DBB1 |
| Synonyms | 1300019I03Rik; MKP-3; MKP3; PYST1 |
| Summary | Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172).[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN304882 | Dusp6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN304882BN | Dusp6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN304882RB | Dusp6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN504882 | Dusp6 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA207414 | Dusp6 CRISPRa kit - CRISPR gene activation of mouse dual specificity phosphatase 6 | 1 657,00 EUR |