PSMB5 Human Gene Knockout Kit (CRISPR)
CAT#: KN209326RB
PSMB5 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Product Images
Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
| Donor DNA | RFP-BSD |
| Symbol | PSMB5 |
| Locus ID | 5693 |
| Components | KN209326G1, PSMB5 gRNA vector 1 in pCas-Guide CRISPR vector KN209326G2, PSMB5 gRNA vector 2 in pCas-Guide CRISPR vector KN209326RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_001130725, NM_001144932, NM_002797 |
| UniProt ID | P28074 |
| Synonyms | LMPX; MB1; X |
| Summary | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
Documents
| Product Manuals |
| FAQs |
|
| SDS |
Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN209326 | PSMB5 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN209326BN | PSMB5 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN209326LP | PSMB5 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN409326 | PSMB5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA103862 | PSMB5 CRISPRa kit - CRISPR gene activation of human proteasome subunit beta 5 | 1 657,00 EUR |