Anti-MLH1 CE/IVD for IHC - Gastrointestinal pathology

Anti-MLH1 CE/IVD for IHC - Gastrointestinal pathology

 

MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.
 
The MLH1 antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. Use of this antibody is indicated, subsequent to clinical differential diagnoses of diseases, as an aid in the identification of MLH1 protein within the context of antibody panels, the patient's clinical history and other diagnostic tests evaluated by a qualified pathologist.

 

 

 

 Esophagus
Colon carcinoma

 

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RUOCE / IVD
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Cat#
Description
Cond.
Price Bef. VAT
IHC409-1
 1ml,Concentrated 
IHC409-100
 0.1ml,Concentrated