Anti-Langerin CE/IVD for IHC - Hematopathology
Langerin, also known as CD207, is a type II, C-type (Ca2+-dependent) transmembrane lectin that is localized in the Birbeck granules of Langerhans cells. Langerhans cells are immature dendritic cells localized in the epidermis and mucosal epithelia that initiate innate and adaptive immune responses to skin-relevant antigens. Tumors derived from Langerhans cells are classified into Langerhans cell histiocytosis (LCH) and Langerhans cell sarcoma (LCS). LCS is a rare dendritic cell tumor defined as a malignant high-grade variant of LCH. Differentiation between LCH, LCS and other tumors is difficult. Langerin has proven helpful in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations, as evaluation of langerin expression is valuable in circumstances where a diagnosis of Langerhans cell histiocytosis is suspected, but cannot be confirmed due to lack of CD1a immunoreactivity. Anti-Langerin is also useful as part of a panel of antibodies against CD1a, CD21, CD23, CD35, and S-100, in the distinction of histiocytic sarcoma, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma, disseminated juvenile xanthogranuloma, and Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy).
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