Nanoprobes

 

Nanoprobes develops nanoparticle products for the research community and has engineered some of the most sensitive reagents and technology for detecting biological molecules.

 

The unique gold labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

 

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, gold labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives Nanoprobes probes a range and versatility which is not available with colloidal gold.

 

Labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold labels; unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy.

 

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

 

1.4 nm Nanogold® probes have been cited in over 250 publications, and Nanoprobes is now developing larger cross-linkable labels in order to offer our customers larger covalently linkable probes with the same advantages.

 

Nanoprobes has developed new technology to expand the uses of gold labels for sensitive and rapid medical diagnostics. They offer a range of ancillary reagents for chemical amplification, staining and imaging. They also develop new applications for metal clusters and nanoparticles as components of new materials, sensors and data storage media.