Human Phospholipase A2 (PLA2G4A) activation kit by CRISPRa
CAT#: GA103582
PLA2G4A CRISPRa kit - CRISPR gene activation of human phospholipase A2 group IVA
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Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
| Symbol | PLA2G4A |
| Locus ID | 5321 |
| Kit Components | GA103582G1, Phospholipase A2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103582G2, Phospholipase A2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103582G3, Phospholipase A2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001311193, NM_024420 |
| UniProt ID | P47712 |
| Synonyms | cPLA2; cPLA2-alpha; PLA2G4 |
| Summary | This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN220972 | PLA2G4A - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN220972BN | PLA2G4A - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN220972LP | PLA2G4A - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN220972RB | PLA2G4A - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN420972 | PLA2G4A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR |