Human Lysosomal acid lipase (LIPA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LIPA
Locus ID	3988
Kit Components	GA102702G1, Lysosomal acid lipase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102702G2, Lysosomal acid lipase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102702G3, Lysosomal acid lipase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000235, NM_001127605, NM_001288979, NR_110233
UniProt ID	P38571
Synonyms	CESD; LAL
Summary	This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]