Human Monoacylglycerol Lipase (MGLL) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MGLL
Locus ID	11343
Kit Components	GA107810G1, Monoacylglycerol Lipase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107810G2, Monoacylglycerol Lipase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107810G3, Monoacylglycerol Lipase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001003794, NM_001256585, NM_007283
UniProt ID	Q99685
Synonyms	HU-K5; HUK5; MAGL; MGL
Summary	This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]