Human ATP citrate lyase (ACLY) activation kit by CRISPRa

CAT#: GA100035

ACLY CRISPRa kit - CRISPR gene activation of human ATP citrate lyase



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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol ACLY
Locus ID 47
Kit Components

GA100035G1, ATP citrate lyase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100035G2, ATP citrate lyase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100035G3, ATP citrate lyase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001096, NM_001303274, NM_001303275, NM_198830
UniProt ID P53396
Synonyms ACL; ATPCL; CLATP
Summary ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

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