Antibody Anti-CD45 (PTPRC) (Hu) from Mouse (IHC045) - unconj.
  • SKU AB-138331
    Specificity

    CD45 (PTPRC)
    Species Reactivity

    Human
    Immunogen

    Recombinant Human CD45 (LCA)
    Host Species

    Mouse
    Isotype

    IgG2a
    Clone

    IHC045
    Clonality (Mono-/Polyclonal)

    monoclonal
    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
    Conjugation

    unconjugated
    Dilution

    Immunohistochemistry (IHC): 1:50 – 1:200
    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
    Intended Use

    for In vitro Diagnostic Use
    Temperature - Storage

    2-8°C
    Temperature - Transport

    cooled
    Manufacturer / Brand

    dianova
    Uniprot_ID

    P08575
    Gene_ID

    5788
    Alias

    CD45, Cluster of Differentiation 45, LCA, Leukocyte Common Antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C
  • Cluster of Differentiation 45 (CD45), also known as Leukocyte Common Antigen (LCA), is a member of the protein tyrosine phosphatase (PTPase) family that is known to regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. CD45 is expressed in most nucleated cells of hematopoietic origin, and is an essential regulator of T- and B-cell antigen receptor signaling. Anti-CD45 positively stains the majority of lymphoid neoplasms, and is highly indicative of lymphoid origin. However, an absence of CD45 does not rule out lymphoid tumours, as certain types of neoplasms lack CD45, such as Hodgkin‘s lymphoma, some T-cell lymphomas, and some leukemias.
  • Antibody Anti-CD45 (PTPRC) (Hu) from Mouse (IHC045) - unconj.
    Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human tonsil tissue section using anti-CD45 (LCA) mouse monoclonal antibody (Clone IHC045).