Antibody Anti-CD45R (B220) (Hu) from Mouse (IHC536) - unconj.
  • SKU AB-179487
    Specificity

    CD45R (B220)
    Species Reactivity

    Human
    Immunogen

    CD45R
    Host Species

    Mouse
    Isotype

    IgG1
    Clone

    IHC536
    Clonality (Mono-/Polyclonal)

    monoclonal
    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
    Conjugation

    unconjugated
    Dilution

    Immunohistochemistry (IHC): 1:50 – 1:200
    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
    Intended Use

    for In vitro Diagnostic Use
    Temperature - Storage

    2-8°C
    Temperature - Transport

    cooled
    Manufacturer / Brand

    dianova
    Uniprot_ID

    P08575
    Gene_ID

    5788
    Alias

    B220, CD45, CD45RA, Cluster of Differentiation 45, L-CA, LCA, Leukocyte Common Antigen, Ly-5, LY5, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
  • CD45R, also known as MB1, is an isoform of CD45 that is a member of the protein tyrosine phosphatase (PTPase) family. CD45R is expressed specifically on the surface of hematopoietic cells, and has demonstrated function as a regulator of the antigen and cytokine receptor signalling of B and T cells. Given that the antigen is located in the membrane of all B cells, with the exception of plasma cells and some mature T cells, Anti-CD45R exhibits specific reactivity with most B lymphocytes. The use of Anti-CD45R is primarily useful in distinguishing B cell lymphomas from T cell lymphomas, with specific reactivity to follicle center cells, mantle cells, some medullary thymocytes, and 80% of B cell lymphomas.
  • Antibody Anti-CD45R (B220) (Hu) from Mouse (IHC536) - unconj.
    Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human tonsil tissue section using anti-CD45R (B220) mouse monoclonal antibody (Clone IHC536).