Stemolecule SB431542

Cat# 04-0010-10

Size : 10mg

Brand : ReproCELL

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Stemolecule™ SB431542

04-0010 / 04-0010-05 / 04-0010-10

Brand: Stemolecule

SB421542 is an inhibitor of the transforming growth factor-beta 1 (TGF-?1) activin receptor-like kinases (ALKs).

CAS Number: 301836-41-9 (anhydrous)
Alternate Name(s):
  • 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Note: shown do not include shipping and handling charges.

Product Information

Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., Aburatani, H., Mishima, H.K., Imamura, T., Miyazono, K., Miyazawa, K. SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells. Cancer Res 63: 7791-7798 (2003).
  • Laping, N.J., Grygielko, E., Mathur, A., Butter, S., Bomberger, J., Tweed, C., Martin, W., Fornwald, J., Lehr, R., Harling, J., Gaster, L., Callahan, J.F., and Olson, B.A. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol Pharmacol 62: 58-64 (2002).
  • Inman, G.J., Nicolás, F.J., Callahan, J.F., Harling, J.D., Gaster, L.M., Reith, A.D., Laping, N.J., and Hill, C.S. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74 (2002).
  • Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S., and Miyazono, K. TGFβ receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311 (2003).
  • Additional Publications

    • Mazza NC; Shuck SC; Lin J: Moxley AM; Termini J; Cookson MR; Wilson MA. DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons. J Neurochem 162:245 (2022).
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    • Lieberman R; Cortes LK; Gao G; Park H; Wang B; Jones PL; Hunter RB; Leonard JP; Barker RH. Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease. PLOS One 17:e0271360 (2022).
    • Gonzàlez BJ; Zhao H; Niu J; Williams DJ; Lee J; Goulbourne CN' Xing Y; Wang Y' Oberholzer J; Blumenkrantz MH; Chen X; LeDuc CA; Chung WK; Colecraft HM; Gromada J; ShenY; Goland RS; Leibel RL; Egli D. Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Commun Biology 5:779 (2022).
    • Yang Y; Laterza V; StuartHT; Michielin F; Gagliano O; Urciuolo A; Elvassore N. Human Pluripotent Stem Cell-Derived Micropatterned Ectoderm Allows Cell Sorting of Meso-Endoderm Lineages. Front Bioeng Biotechnol 10:907159 (2022).
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    • Khalili M; Zarebkohan A; Dianat-Moghadam H; Panahi M; Andre H; Alizadeh E. Corneal endothelial cell sheet bioengineering from neural crest cell-derived adipose stem cells on novel thermo-responsive elastin-mimetic dendrimers decorated with RGD. Chem Engr J 429:132523 (2022).
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    • Mok RSF. Morphology and Connectivity Impairments in Rett Syndrome Human Stem Cell-Derived Neurons. Ph. D. Thesis, Univ of Toronto : (2020).
    • EMBO Mol Med. Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids. e12523: (2020).
    • Mou Y; Dong Y; Chen Z; Denton KR; Duff MO; Blackstone C; Zhang S-C; Li X-J. Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia. Acto Neuropathologica Commun 8:214 (2020).
    • Choi SY; Lee J-H; Chung A-Y; Jo Y; Shin J-h; Park H-C; Kim H; Lopez-Gonzalez R; Ryu JR; Sun W. Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis. Cell Death Disease 11:888 (2020).
    • Sun X-J; Li Ming-Xing; Gong C-Z; Chen J; Nasb M; Shah ZA; Rehan M; Li Y-J; Chen C. Temporal expression profiles of lncRNA and mRNA in human embryonic stem cell-derived motor neurons during differentiation. Peer J ://doi.org/10.7717/peerj.10075 (2020).
    • Barbar L; Rusielewica T; Zimmer M; Kalpana K; Fossati V. Isolation of Human CD49f+ Astrocytes and In Vitro iPSC-Based Neurotoxicity Assays. STAR Protocols :doi.org/10.1016/j.xpro.2020.100172 (2020).
    • Sato T; Higashioka K; Kakurai H; Yamamoto T; Goshima N; Ueno M; Sotozono C. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Rep 13:352-365 (2019).
    • Zhu Z; Mesci P Bernatchez JA Gomple RC; Wang X; Schafer ST; Wettersten HI; Beck S; Clarck AE; Wu Q; Prager BC; Kim LJY; Dhanwani R; Sharma S; Garancher A: WEis SM; Mack SC; Negraes PD; Trujillo CA; Penalva LO; Feng J; Lan Z; Zhang R; Wessel AW; Dhawan S; Diamond MS; Chen CC; Wechsler-Reya RJ; Gage FH; Hu H; Siqueira-Neto JL; Muotri AR; Gheresh DA; Rich JN. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell 26:187-204.E10 (2020).
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    • Shafa M; Walsh T; Panchalingam KM; Richardson T; Menendez L; Tian X; Babu SS; Dadgar S; Beller J; Yang F; Baghbaderani BA. Long-Term Stability and Differentiation Potential of Cryopreserved cGMP-Compliant Human Induced Pluripotent Stem Cells. Int J Molecular Sci 21:108 (2020).
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    • Yuva-Aydemir Y; Almeida S; Krishnan G; Gendron TF; Goa F-B. AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD. Nature Commun 10:5466 (2019).
    • Leitner D; Ramamoorthy M; Dejosez M; Zwaka TP. Immature mDA Neurons Ameliorate Motor Deficits in a 6-OHDA Parkinson's Disease Mouse Model and are Functional after Cryopreservation. Stem Cell Res in press:doi.org/10.1016/j.scr.2019.101617 (2019).
    • Nagaraja S; Quezada MA; Gillespie SM; Arzt M; Lennon JJ; Woo PJ; Hovestadt V; Kambhampati M; Filbin MG; Suva ML; Nazarian J; Monje M. Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State. Molecular Cell 76:1-16 (2019).
    • Durens M; Nestor J; Herold K Niescier RF; Lunden FW; Phillips AW; Lin Y-C; Nestor MW. High-content interrogation of human induced pluripotent stem cell-derived cortical organoid platforms. bioRxiv http://dx.doi.org/10.1101/697623. : (2019).
    • de Souza JS; Ferreira DR; Herai R; Carromeu C; Torres LB; Araujo BHS; Cugola F; Maciel RMB; Muotri AR; Giannocco G. Altered Gene Expression of Thyroid Hormone Transporters and Deiodinases in iPS MeCP2-Knockout Cells-Derived Neurons. Molecular Neurobiol in press:https://doi.org/10.1007/s12035-019-01645-2 (2019).
    • Wang Y; Gao J; Wang H; Wang M; Wen Q; Guo J; Su P; Shi L; Zhou W; Zhou J. R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling. Stem Cell Res Therap 10:136 (2019).
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    • Zhang Y; Zhang Y; Li M; Mend F; Yu Z; Chen Y; Cui G. Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells. Oncol Rep In Press:https://doi.org/10.3892/or.2019.7088 (2019).
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    • Winston TS; Suddhapas K; Wang C; Ramos R; Soman P; Ma Z. Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells. Stem Cells Int Article ID: 5654324:11 pages (2019).
    • Wu C; Watts ME; Rubin LL. MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis. Cell Reports 26:1143-1156.e5 (2019).
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    • Sun X; Song J; Huang H; Chen H; Qian K. Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells. Stem Cell Res Therapy 9:315 (2018).
    • Javed AO; Li Y; Muffat J; Su K-C; Cohen MA; Lungjangwa T; Auborg P; Cheeseman IM; Jaenisch R. Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Rep 25:368-382.e5 (2018).
    • Whitworth DJ; Limnios IJ; Gauthier M-E; Weeratunga P; Ovchinnikov DA; Baillie G; Grimmond SM; Graves JAM; Wolvetang EJ. Platypus Induced Pluripotent Stem Cells: the Unique Pluripotency Signature of a Monotreme . BioRXiv 43306: (2018)
    • Chhabra S; Liu L; Goh R; WarmflashA. The timing of signaling events in the BMP, WNT, and Nodal cascade determines self-organized fate patterning in human gastruloids. bioRxiv 2018:http://dx.doi.org/10.1101/440164 (2018).
    • Chen Z;l Ren X; Xu X; Zhang Z; Hui Y; Liu Z; Shi L; Fang Y; Ma L; Liu T; Terheyden-Keighley D; Liu L; Zhang X. Genetic Engineering of Human Embryonic Stem Cells for Precise Cell Fate Tracing during Human Lineage Development. Stem Cell Rep in press:https://doi.org/10.1016/j.stemcr.2018.09.014 (2018).
    • Peng Y; Xie M; Duan X; Hu L; Yu J; Zeng S; Wange Y; Ouang Q; Lu G; Lin G; Sun Y. Generation of a luciferase-expressing human embyronic stem cell line: NERCe002-A-2. Stem Cell Research doi.org/10.1016/j.scr.2018.02.010: (2018).
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    • Schaefer SA; Higashi A; Loomis B; Schrepfer T; Wan G; Corfas G; Dressler GR; Duncan RK. From Otic Induction to Hair Cell Production: Pax2EGFPCell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model. Stem Cells Development 27:237-251 (2018).
    • Lee H; Haller C; Manneville C; Doll T; Fruh I; Gubser Keller C; Richards SM; Ibig-Rehm Y; Patoor M; Goette M; Bouchez LC; Mueller M. Identification of Small Molecules Which Induce Skeletal Muscle Differentiation in Embryonic Stem Cells via Activation of the Wnt and Inhibition of Smad2/3 and Sonic Hedgehog Pathways. Stem Cells 34:299-310 (2016).
    • Wang Y; Qin J; Wang S; Zhanfg W; Duan J; Zhang J; Wang X; Yan F; Chang M; Liu X; Feng B; Liu J; Pei X; Pei X. Conversion of human gastric epithelial cells to multipotent endodermal progenitors using defined small molecules. Cell Stem Cell 19:449 (2016).
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    • Zhang, Z; Wu, W-S. Sodium Butyrate Promotes Generation of Human Induced Pluripotent Stem Cells Through Induction of the miR302/367 Cluster. Stem Cells and Development. 22(16): 2268-2277 (2013).
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