Stemfactor LIF, Mouse Recombinant

Cat# 03-0011

Size : 1ml,10μg/ml

Brand : ReproCELL

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Stemfactor™ LIF, Mouse Recombinant

03-0011 / 03-0011-100

Brand: Stemfactor

Mouse LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of mouse PSCs by suppressing spontaneous differentiation.

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Product Information

Mouse LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of mouse embryonic stem cells by suppressing spontaneous differentiation1,2. Leukemia Inhibitory Factor (LIF) has additional functions such as cholinergic neuron differentiation, bone and fat metabolism, mitogenesis of certain factor-dependent cell lines and promotion of megakaryocyte production in vivo. Mouse LIF is an approximate 20 kDa protein containing 202 amino acid residues.


03-0011 Specifications Sheet
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    Niwa, H., Ogawa, K., Shimosato, D., and Adachi, K.) A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460: 118-122 (2009).
  • Xu, J., Wang, F., Tang, Z., Zhan, Y., Zhang, J., Yan, Q., Xiong, Y., Xie, X., Wu, J., and Zhang, S. Role of leukaemia inhibitory factor in the induction of pluripotent stem cells in mice. Cell Biol Int 34: 791-797 (2010).
  • Fukunaga, N., Teramura, T., Onodera, Y., Takehara, T., Fukuda, K., and Hosoi, Y. Leukemia inhibitory factor (LIF) enhances germ cell differentiation from primate embryonic stem cells. Cell Reprogram 12: 369-376(2010).
  • Metcalf D. The unsolved enigmas of leukemia inhibitory factor. Stem Cells 21: 5-14 (2003).
  • Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A., and Gough, N.M. Myeloid leukemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336: 684-687(1988).
  • Metcalf, D., Hilton, D.J., and Nicola, N.A. Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells. Leukemia 2: 216-221(1988).
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